According to one report, about one in four adults in the United States has severe joint pain. With prescribed medications not as effective as promised or with a huge side effect profile, many are looking for better pain management options while others try to supplement what they already have.

Given the chatter that natural compounds can help treat joint pain, people are now using compounds like CBD and caffeine, which we will describe below.

Brief medical history and use of CBD in pain control

Cannabidiol was legalized for use in 2018 after the passing of the Farm Bill that legalized CBD in over fifty US states. Companies therefore take advantage of the opportunity to meet demand. Among the products sold in the market, you may find CBD cream for joint pain, foods, tinctures, oils, etc.

CBD research shows that it can help with inflammation, pain, and many other diseases. This can be done without causing the poisoning normally associated with THC. This is because, unlike tetrahydrocannabinol, CBD does not work by binding to CB1 and CB2 receptors.

Cannabidiol accomplishes a therapeutic function by increasing the concentration of anandamide, an endogenous cannabinoid that regulates the immune system, relieves anxiety and depression, and promotes sleep.

CBD also interacts with other signaling pathways such as the serotonin receptors, which are responsible for depression and pain intolerance.

The compound also stimulates the release of dopamine and thus promotes well-being. Just like caffeine, it also works through the adenosine receptors and thus influences pain perception and response.

CBD side effects, when they get into your body, can include sluggishness, irritation, nausea, or vomiting.

Caffeine for pain management

Over 85% of American adults consume caffeine. that’s about 150 million daily coffee drinkers. In addition to stimulating properties that aid with focus, memory, metabolism, athletic performance, and increased alertness, caffeine also has anti-inflammatory effects.

Caffeine works through adenosine receptors in the brain that affect how to tolerate pain and other stressors. By binding and preventing activity at the receptors, this provides pain relief. It also increases the synthesis and secretion of the neurotransmitter dopamine and molecules known as endorphins.

Endorphins are the body’s natural opioids that help with pain relief. In addition, caffeine also contains various antioxidants called polyphenols that help the body excrete free radicals, the accumulation of which can lead to cancer growth. Caffeine can also reduce post-workout muscle soreness by around 50% and is commonly used to supplement medications like aspirin and ibuprofen.

However, the effects of caffeine depend on the type of joint pain and the concentration of caffeine. Caffeine has various side effects including anxiety, jitter, abnormal heartbeat, increased blood pressure, insomnia, bowel problems, dehydration by stimulating salt and water excretion, induction tolerance and also addicting.

CBD and caffeine for the perfect CBD cream

Inflammation is the body’s natural response to injury. If left unregulated, it can damage body tissues, leading to pain and more severe conditions like cancer. This is mediated by inflammatory molecules called cytokines.

Because of the effects of CBD and caffeine in treating pain, you can therefore enjoy synergistic effects of both products when applied through a cream. Creams are made by adding CBD oil to butter or other oils to act as a “vehicle” for transporting the compound.

There are no absolute doses for the amount of CBD cream you should use for various joint pains, but you can experiment with low amounts before switching to higher ones. You should do this while monitoring your body’s feedback so that you know what is working best for you. However, the effects will depend on age, gender, body weight, the blood supply to the area, the concentration of compounds, genetics, and your pain tolerance.

Other Pain Management Practices

For best results, experts recommend using the products in combination with:

  • Yoga, meditation and tolerable exercise
  • Better sleep practices
  • Good nutrient dense food that promotes regeneration
  • Electrolytes and vitamins for immune regulation
  • Massage the affected area to improve blood supply and relieve tension

Buying caffeinated CBD cream

The CBD market right now has dubious people that you could take advantage of with average products. To protect yourself from this, you need to develop a keen eye for choosing a reputable company.

This can be achieved by reviewing ratings and reviews on their website, analyzing third-party laboratory test results for exact concentrations and contaminants, and whether the company makes health claims about its products in marketing.


The above information is not medical advice, so you should never replace any prescribed medication with these products. Be careful before applying the cream, as it can worsen some underlying diseases or cause harmful reactions with over-the-counter medications.

Ask your chiropractor before applying caffeine and CBD cream as the compounds need more specific research.


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