Research Finds Hashish-Like Substances Launched After Train

  • New research has shown that exercise can stimulate microbes in our gut.
  • These microbes can produce pain relievers and anti-inflammatory substances called endocannabinoids.
  • It is important to talk to your doctor before starting any exercise program, especially after a recent injury or if you have cardiovascular disease.

New research has shown that exercise can increase the production of our body’s own cannabis-like substances that reduce inflammation and could potentially help prevent conditions like arthritis, heart disease and even cancer.

The study, published in the journal Gut Microbes, found that people with arthritis not only experienced less pain, but also lower levels of markers of inflammation called cytokines and increased levels of endocannabinoids, which are naturally produced by gut microbes in our microbiome.

“The microbiome plays a key role in many body functions such as digestion and the immune system,” Elena A. Ivanina, DO, director of neurogastroenterology and motility at Lenox Hill Hospital in New York, told Healthline.

A research team from the University of Nottingham School of Medicine in the UK recruited 78 people with knee osteoarthritis for the study.

38 participants did 15 minutes of muscle strengthening exercise daily for 6 weeks while the other 40 did nothing.

The researchers found that those who did exercise not only reduced their pain, but also had more microbes in their gut that produce anti-inflammatory substances.

Participants also had lower cytokine levels (an indicator of inflammation) and higher endocannabinoid levels.

According to researchers, at least a third of the gut microbiome’s anti-inflammatory effects were due to the increased endocannabinoids.

“Endocannabinoids are naturally occurring neurotransmitters that are made in the body,” said Peter C. Lascarides, DO, attending physician in pain management at Northwell Health’s Northern Westchester Hospital in Mount Kisco, New York.

He added that these substances are “tied” to various functions and affect things like mood, energy, memory, appetite, and pain.

Amrita Vijay, PhD, research fellow at the University of Nottingham School of Medicine and first author of the article, admitted she was surprised by the results.

“The results are new because we may have found an important link between the interaction of substances produced by gut microbes with the substances produced by our own bodies that tell us how exercise reduces inflammation,” said they Healthline in an emailed statement.

According to Vijay, the results of this study show that lifestyle interventions like exercise can affect endocannabinoid production.

“This is a timely discovery, especially at a time when there is growing interest in the use of cannabidiol and other related supplements to reduce inflammation,” she said.

Researching how to reduce inflammation in the body can be key to improving multiple health systems.

Lascarides found that inflammation is a natural part of the body’s defense mechanism. But when inflammation becomes chronic, it can lead to disease and disability.

“The effects of chronic inflammation can lead to conditions such as fatigue, pain, mood disorders, and gastrointestinal and immune disorders,” he said.

According to Ivanina, the microbiome plays a vital role in training and developing key components of our innate and adaptive immune systems.

“The microbiome can also make certain vitamins and amino acids, including the B vitamins and vitamin K,” she said.

However, it is a delicate system. What we put into our body can easily disturb it.

“Antibiotics disrupt the microbiome and its function a lot,” said Ivanina. “In addition, alcohol, smoking, stress, lack of sleep, lack of exercise and a lack of fiber and prebiotics in the diet disrupt the microbiome.”

“Regular aerobic exercise can lead to an improvement in pain perception, especially in chronic pain conditions,” said Lascarides. “It is believed that this is due to the release of neurotransmitters called endorphins during exercise.”

As beneficial as exercise can be for people with chronic pain, he warned that a doctor should approve new exercise programs, “especially after a recent injury or cardiovascular disease.”

Ivanina agreed, adding that it can be dangerous to exercise with certain pains.

“Therefore, the individual situation should be discussed with a doctor,” she said.

New research has found that exercise can stimulate microbes in our gut that produce pain reliever and anti-inflammatory substances called endocannabinoids.

Experts say chronic inflammation can lead to many serious health outcomes.

They also say that while exercise can benefit the body in many ways, it is important to speak to your doctor before starting any exercise program, especially after a recent injury or if you have cardiovascular disease .